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  Cystic Fibrosis .  if you want to understand the topic of  cystic fibrosis , then this is best place for you. Because we teach medicine for preparation of exams. we will teach you core concepts of  cystic fibrosis ...! What is Cystic Fibrosis? Cystic fibrosis is  an inherited disorder that damages your lungs, digestive tract and other organs . Genetics: Autosomal recessive defect in CFTR gene on chromosome 7, commonly a deletion of Phe508. Most common lethal genetic disease in Caucasian population. Pathophysiology: CFTR encodes an ATP-gated Cl− channel that secretes Cl− in lungs and GI tract, and reabsorbs Cl− in sweat glands. Most common mutation is misfolded protein  leading to protein retained in RER and not transported to cell membrane, causing decreased  Cl− (and H2O) secretion, increased intracellular Cl− results in compensatory increase in Na+ reabsorption via epithelial Na+ channels (ENaC)  leading to H2O reabsorption , hence ...

 Acute Pancreatitis .  if you want to understand the topic of  acute pancreatitis , then this is best place for you. Because we teach medicine for preparation of exams. we will teach you core concepts of acute pancreatitis ...! What is Acute pancreatitis? Acute pancreatitis is a condition where the pancreas gets inflammed(swollen)  in short period of time. Pancreas is an organ which secretes different metabolic enzymes and chemicals which help in digestion. Causes: Idiopathic,  Gallstones,  Ethanol,  Trauma,  Steroids,  Mumps,  Autoimmune disease,   Scorpion sting,  Hypercalcemia/Hypertriglyceridemia (> 1000 mg/dL),  ERCP,  Drugs (eg, sulfa drugs, NRTIs, protease inhibitors) Clinical Features: Fever, tachycardia, hypotension Dyspnea, tachypnea &/or basilar crackles Abdominal tenderness &/or distension Cullen sign: periumbilical bluish coloration indicating hemoperitoneum Grey Turner sign: reddis...

Celiac Disease . if you want to understand the topic of  celiac disease , then this is best place for you. Because we teach medicine for preparation of exams. we will teach you core concepts of  celiac disease... What is Celiac Disease? Celiac Disease is an  Autoimmune-mediated intolerance of gliadin (gluten protein found in wheat) leading to malabsorption and steatorrhea. Clinical Menifestations: Gastrointestinal Diarrhea, ± steatorrhea, weight loss Abdominal pain Flatulence/bloating Late manifestations: ulcerative jejunitis, enteropathy-associated T-cell lymphoma Mucocutaneous Dermatitis herpetiformis Atrophic glossitis Endocrine Vitamin D deficiency Secondary hyperparathyroidism Bone disorders Osteomalacia/osteoporosis (adults) Rickets (children) Hematologic Iron deficiency anemia Neuropsychiatric Peripheral neuropathy Depression/anxiety Association with Autoimmunity: Patients with type 1 diabetes are at high risk of celiac disease,possibly related to multiple shared...